Figure 838

Development of interstitial cellular infiltrates in the renal cortex and medulla after ureteral obstruction. After ureteral obstruction there is a rapid influx of macrophages and suppressor T lymphocytes in the cortex and medulla (A) that is accompanied by an increase in urinary thromboxane B2 and a decrease in the glomerular filtration rate. The production of thromboxane A2 by the infiltrating macrophages (B) contributes to the renal vasoconstriction of chronic urinary tract obstruction. After release of the obstruction the cellular infiltration is slowly reversible, requiring several days to revert to near normal levels (C) [50,51].

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