Figure 86

Laboratory findings in sarcoidosis. The diagnosis of sarcoidosis depends on the demonstration of the characteristic pathologic lesion of noncaseating granulomas within the affected organs. Several laboratory abnormalities characterize sarcoidosis and are useful in supporting but not establishing the diagnosis. Hyperglobulinemia is a principal feature, being present in two thirds of cases. About half of patients have liver involvement, with some abnormality of liver function tests; anergy is present in about half of patients; leukopenia is present in 25% to 30%. Hypercalciuria is common because of increased levels of calcitriol. In 50% to 60% of patients levels of angiotensin-converting enzymes are elevated. Fever is present in about one third of patients.

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