Figure 86

The structure of class I and II molecules. Comparison of the crystalline structures of classes I and II molecules has revealed overall structural similarity, with a few significant differences. A, Class I molecules have a groove with deep anchor pockets at each end (a "pita pocket"). These pockets restrict the binding of peptides to those of eight to nine amino acid residues in length. B, The peptide-binding groove of class II molecules is more flexible and relatively open at one end, more like a "hotdog bun," permitting larger peptides from 13 to 25 amino acid residues in length to bind.

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