Figure 914

The making of a polyclonal antilymphocyte preparation. Antilymphocyte globulin (ALG) or antithymocyte globulin (ATG) are polyclonal antisera derived from immunization of lymphocytes, lym-phoblasts, or thymocytes into rabbits, goats, or horses. These agents have been used prophylactically as induction therapy during the early posttransplantation period and for treatment of acute rejection. Most centers reduce concomitant immunosuppression (eg, stop cyclosporine and lower azathioprine dose) to decrease infectious complications. Antithymocyte gamma globulin (ATGAM) is the only FDA-approved polyclonal preparation. Two rabbit immunoglobulin preparations, raised by immunization with thymocytes or with a human lympho-blastoid line, are scheduled for phase III multicenter testing versus ATGAM or OKT3, respectively. Potential side effects include fever, chills, erythema, thrombocytopenia, local phlebitis, serum sickness, and anaphylaxis. The potential for development of host anti-ALG antibodies has not been a significant problem because of the use of less immunogenic preparations and probably because ALG suppresses the immune response to the foreign protein itself [2,10].

Fuse with polyethylene glycol

Grow in I mass culture

Fuse with polyethylene glycol

Grow in I mass culture

Select desired hybrids

Produce in

Antibody

Select desired hybrids

Produce in

- animals

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

Get My Free Ebook


Post a comment