Figure 926

Apoptosis-schematic of histologic changes in tubular epithelium. The process begins with condensation of the cytoplasm and of the nucleus, a process which involves endonucleases, which digest the DNA into ladder-like fragments characteristic of this process. The cell disintegrates into discrete membrane-bound fragments, so-called "apoptotic bodies." These fragments may be rapidly extruded into the tubular lumen or phagocytosed by neighboring epithelial cells or inflammatory cells. (Modified from Arends, et al. [10]; with permission.)

Tubular cell injury

H Toxin

Tubular cell injury

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