Figure 97

The distinctive features of the membra-noproliferative glomerulonephritis. This disorder, called cryoglobulinemic glomerulonephritis, occurs only in patients with type II mixed cryoglobulinemia, especially in the acute stage of the disease [4,14]. In about 20% of patients with type II mixed cryoglobulinemia, a less distinctive picture of lobular membranoproliferation is found, whereas an additional 20% exhibit mild mesangial proliferation. These various types of histologic lesions can be found by repeat biopsies in the same patient during different stages of the disease.

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