General Nephrotoxic Factors

The nephron

Cortex

The nephron

Cortex

t 1 Lithium ! ! Ischemia

Vulnerability of the kidney

Sites of renal damage

^ ACE inhibitors ^ NSAIDs ( ) Aminoglycosides

Acyclovir ^^^^ Cisplatinum HgCl2

t 1 Lithium ! ! Ischemia

Vulnerability of the kidney

•Important blood flow (1/4 cardiac output)

• High metabolic activity

• Largest endothelial surface by weight •Multiple enzyme systems •Transcellular transport •Concentration of substances •Protein unbinding

•High O2 consumption/delivery ratio in outer medulla

0 0

Post a comment