Hyperoxaluria

FIGURE 6-31 (see Color Plate)

Wi4L

FIGURE 6-31 (see Color Plate)

A, Calcium oxalate crystals (arrow) seen on light microscopy. B, Dark field microscopy. When hyperoxaluria is sudden and massive (such as after ethylene glycol ingestion) acute renal failure develops. Otherwise, in most cases of hyperoxaluria the overload is insidious and chronic. As a result, interstitial fibrosis, tubular atrophy, and dilation result in chronic TIN with progressive renal failure. The propensity for recurrent calcium oxalate nephrolithiasis and consequent obstructive uropathy contribute to the tubulointerstitial lesions.

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