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FIGURE 4-6 (Continued)

FIGURE 4-6 (Continued)

C, Electron microscopy scan of a normal erythrocyte and a sickle cell. D-L, This series of sickle cells show many possible formations of sickled erythrocytes. The variety of shapes results from the intracellu-lar localization of the polymers. In banana-or sickle-shaped cells the polymers have formed bundles of fibers oriented along the long axis of the cell. In cells with a holly-leaf shape (panel E), the hemoglobin fibers point in different directions.

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