Hepatocellular necrosis

Labetalol only, idiosyncratic reaction

Withdrawal syndrome

Acute overshoot in heart rate with increased myocardial oxygen demand

Unstable angina

due to increase in number and/or sensitivity of p-adrenergic receptors

Myocardial infarction

during chronic blockade


Increased a-adrenergic tone; reduced lipoprotein lipase activity

Increased total triglycerides

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