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Clindamycin

600-1200 mg IV or 600 mg po q6h

3-6 wk

Slower resolution than with sulfa; C. difficile colitis

Spiramycin

1 g po tid or qid

3-6 wk

In pregnancy or sulfa allergy with pyrimethamine; CNS data limited

Antibiotic therapy for Toxoplasma gondii infection. (Adapted from Fishman [9]; with permission.)

*Active infection: twice weekly blood counts are necessary to detect bone marrow suppression resulting from therapy.

Lifelong prophylaxis after acute infection is recommended in transplant and AIDS patients. ^Investigational: trimetrexate, atovaquone, macrolides, gamma interferon.

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