Ischemia e

Basal 24h control

Posttreatment days

Endothelin-1 (ET-1) receptor blockade ameliorates severe ischemic acute renal failure (ARF) in rats. The effect of an ETA receptor antagonist (BQ123) on the course of severe postischemic ARF was examined in rats. BQ123 (light bars) or its vehicle (dark bars) was administered 24 hours after the ischemic insult and the rats were followed for 14 days. A, Survival. All rats that received the vehicle were dead by the 3rd day after ischemic injury. In contrast, all rats that received BQ123 post-ischemia survived for 4 days and 75% recovered fully. B, Glomerular filtration rate (GFR). In both groups of rats GFR was extremely low (2% of basal levels) 24 hours after ischemia. In BQ123-treated rats there was a gradual increase in GFR that reached control levels by the 14th day after ischemia. C, Serum potassium. Serum potassium increased in both groups but reached significantly higher levels in vehicle-treated compared to the BQ123-treated rats by the second day. The severe hyperkalemia likely contributed to the subsequent death of the vehicle treated rats. In BQ123-treated animals the potassium fell progressively after the second day and reached normal levels by the fourth day after ischemia. (Adapted from Gellai et al. [5]; with permission.)

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