Short portal vein


Pathways of antidiuretic hormone release. Antidiuretic hormone is responsible for augmenting the water permeability of the cortical and medullary collecting tubules, thus promoting water reabsorption via osmotic equilibration with the isotonic and hypertonic interstitium, respecively. The hormone is formed in the supraoptic and paraventricular nuclei, under the stimulus of osmoreceptors and baroreceptors (see Fig. 1-11), transported along their axons and secreted at three sites: the posterior pituitary gland, the portal capillaries of the median eminence, and the cerebrospinal fluid of the third ventricle. It is from the posterior pituitary that the antidi-uretic hormone is released into the systemic circulation [6]. SON—supraoptic nucleus; VP—vasopressin; NP—neurophysin.

Exon 1

Exon 2

Exon 3

Pre-pro-vasopressin (164 AA)

Signal peptide

AVP — Gly— Lys — Arg — Neurophysin II —Arg— Glycopeptide (Cleavage site)


AVP — Gly— Lys — Arg — Neurophysin II —Arg— Glycopeptide iz

Products of pro-vasopressin

Neurophysin II


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