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Structural and functional recovery of the nephron

Intact tubular epithelium

Intact tubular epithelium

Loss of polarity, tightjunction integrity, cell-substrate adhesion, simplification of brush border

Cytoskeleton | Extracellular matrix 0 Na+/K+=ATPase •c p Integrin o RGD peptide

Cell death

Cast formation and tubuler obstruction

Cell death

Necrosis

Necrosis

Sloughing of viable and nonviable cells with intraluminal cell-cell adhesion

Sloughing of viable and nonviable cells with intraluminal cell-cell adhesion

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