Info

Absorption, %

First-pass hepatic

Peak concentration

Route of elimination

Active metabolite

Plasma half-life, h

Dose reduction

Verapamil

>90

70%—80%

1-2 h (tablet) 5 h (SR caplet) 7-9 h (SR pellet) 11 h (COER)

Liver

Yes

4-12 (tablet) 12 (SR pellet)

No

Amlodipine

>90

Minimal

6-12 h

Liver

No

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