Dapsone (po) with

100 mg/d

Methemoglobinemia; G6PD;

TMP (po/IV)

15-20 mg/kg/d (900 mg)

may be tolerated in sulfadiazine allergy

Clindamycin (IV/po)

600-900 mg q 6 h

Methemoglobinemia; diarrhea

and primaquine

15-30 mg base po qd

(pyrimethamine for primaquine)

Trimetrexate (IV) with

30-45 mg/m2/d

Leukopenia, anemia;

folinic acid (po)

80-100 mg/m2/d

thrombocytopenia; relapse common


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