Info

Capreomycin (Capastat)

15 mg/kg IM or IV

15-30 mg/kg

Auditory and vestibular toxicity, renal damage

Kanamycin (Kantrex, and others)

15 mg/kg IMtt

15-30 mg/kg

Auditory toxicity, renal damage

Streptomycin**

250-500 mg bid^

20-40 mg/kg IM

Vestibular toxicity, renal damage

Cycloserine (Seromycin, and others)

250-500 mg bid

15-20 mg/kg

Psychiatric symptoms, seizures

Ethionamide (Trecator-SC)

500-750 mg bid

15-20 mg/kg

Gastrointestinal and hepatic toxicity

Ciprofloxacin (Cipro)

200-400 mg q12h or

Not recommended

Nausea

Ofloxacin (Floxin)

400-800 mg/day

Not recommended

Nausea

*Rifamate (containing rifampin 300 mg plus isoniazid 150 mg) is also available tCan be given orally or parenterally. Pyridoxine should be given to prevent neuropathy in malnourished or pregnant patients and those with alcoholism or diabetes. For intermittent use after a few weeks to months of daily dosage, the dosage is 15 mg/kg twice/wk (max. 900 mg).

♦Available orally or intravenously. For intermittent use after a few weeks to months of daily dosage, the dosage is 600 mg twice/wk.

§For intermittent use after a few weeks to months of daily dosage, the dosage is 40-50 mg/kg twice/wk (max. 3 g).

^Daily dosage should be 25 mg/kg/d if organism isoniazid-resistant or during first 1 to 2 months; decrease dosage if renal function diminished. For intermittent use after a few weeks to months of daily dosage, the dosage is 50 mg/kg twice/wk.

**Temporarily not available in the United States.

ttFor patients > 40 years old, 500 to 750 mg/d or 20 mg/kg twice/wk; decrease dosage if renal function is diminished. Some clinicians change to lower dosage at 60 rather than 40 years of age.

♦♦Some authorities recommend pyridoxine 50 mg for every 250 mg of cycloserine to decrease the incidence of adverse psychiatric effects.

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