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Pathogenesis of renal lesion associated with analgesic abuse

-Cortex- normal

Outer medula- patchy tubular damage a. tubular dilatation b. increased interstitial tissue c. casts: pigment

Papilla- possible microscopic changes

-Cortex- normal

Outer medula- patchy tubular damage a. tubular dilatation b. increased interstitial tissue c. casts: pigment

Papilla- possible microscopic changes

Stage II

Stage II

Stage III

Cortex- normal

Outer medula- increase in changes

Papilla- necrosis and atrophy attached or separated

Cortex-

a. atrophy area overlying necrotic papilla b. hypertrophy

Papilla- atrophic, necrotic

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