FIGURE 10-4 (Continued)

C, Changes in renin are associated with commensurate changes in the secretory rate of aldosterone. Although a correlation exists between the increase in renin and that of aldosterone, the latter increases to a greater degree in late pregnancy. This observation suggests that other factors may regulate secretion to a greater degree than does angiotensin II in late gestation. Urinary aldosterone increases in late gestation to a greater degree than does plasma aldosterone, which may reflect an increased production of the 3-oxo conjugate measured in urine. D, Despite the marked increases in aldosterone during pregnancy, 24-hour urinary sodium and potassium excretion remain in the normal range. PP— postpartum. (From Wilson and coworkers [7]; with permission.)

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