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*Fanconi's syndrome as the most severe manifestation. tOnly seen with intermediate to high dose regimens. 'Only seen when given in combination with mitomycin C. §Hemolytic-uremic syndrome as the most severe manifestation. ^Frequent with antineoplastic doses, rare in doses used for hypercalcemia.

*Fanconi's syndrome as the most severe manifestation. tOnly seen with intermediate to high dose regimens. 'Only seen when given in combination with mitomycin C. §Hemolytic-uremic syndrome as the most severe manifestation. ^Frequent with antineoplastic doses, rare in doses used for hypercalcemia.

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