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FIGURE 2-27 (see Color Plate)

FIGURE 2-27 (see Color Plate)

Antineutrophil cytoplasmic autoantibodies (ANCA). Frequently, ANCA are found in crescentic glomerulonephritis, particularly type III (Figure 2-24). Two varieties are seen (on alcohol-fixed slides). A, C-ANCA are due to antibodies reacting with cyto-plasmic granule antigens (mainly pro-teinase-3). B, P-ANCA are due to antibodies reacting with other antigens (mainly myeloperoxidase).

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