John D Pirsch Jon S Odorico Hans W Sollinger

In the United States, diabetes mellitus is the third most common disease and fourth leading cause of death from disease. Diabetes is the leading cause of blindness, the number one cause of amputations and impotence, and one of the most frequently occurring chronic childhood diseases. Diabetes is also the leading cause of end-stage renal disease in the United States, with a prevalence rate of 31% compared with other renal diseases. Diabetes is also the most frequent indication for kidney transplantation, accounting for 22% of all transplantation operations.

Increasingly, pancreas transplantation is being offered to patients who would benefit from kidney transplantation (called simultaneous pancreas-kidney transplantation) or who have had a previously successful kidney transplantation (called sequential pancreas after kidney transplantation). Relatively few transplantation centers are performing pancreas transplantation alone in patients with severe life-threatening complications of diabetes. Pancreas transplantation has been criticized because of the increased morbidity associated with the procedure and lack of controlled trials demonstrating significant benefit to the secondary complications of diabetes. However, many of these criticisms have been overcome with improvement in surgical techniques and pancreas transplantation preservation and with more potent immunosuppressive regimens. The relative frequency of pancreas transplantation, common surgical procedures, and outcomes of patients undergoing pancreas transplantation are discussed.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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