Length of the Loops of Henle in Animals Correlated with Kidney Concentrating Capacity

Sickle cell trait: Progressive loss in 70 y of inner medullary concentrating function

Sickle cell anemia:

A. Up to about 15 y: reversible concentrating defect

B. Over 15 y: complete and irreversible loss of inner medullary concentrating function

Sickle cell kidney

Beaver kidney Long loops of Henle not functioning or absent

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