Mhc I And Ii Characteristics

Class I

Class II

Composed of HLA-A, -B, and -C

Composed of HLA-DR, -DQ, and -DP

Ubiquitous distribution

Restricted distribution

Autosomal codominant

Autosomal codominant

Target for immune effector mechanism

Major role in immune response

Serologic and molecular detection

induction

Heterodimer noncovalently linked

Serologic, molecular, and cellular

Heavy chain (a):

detection

Contains variable regions

Heterodimer noncovalently linked

Confers human leukocyte antigen

a Chain:

specificity

Nonvariable in HLA-DR

Light chain (^-microglobulin):

Contains variable regions in HLA-DQ

Invariant

and -DP

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