Reassembly of the Permeability Barrier

Reutilization of existing junctional components

Synthesis of new junctional components

Synthesis of new junctional components

Nonpolarized renal epithelial cells

Cell death Apoptosis Necrosis

Polarized renal epithelial cells

Intact intercellular junctions

Nonpolarized renal epithelial cells

Compromised intercellular junctions

Nonpolarized renal epithelial cells

Damaged disassembled intercellular junctions

Cell death Apoptosis Necrosis t

Deplete ATP

Short-term ATP depletion 0-1 h

Replete ATP

Long-term ATP depletion 2.5-4 h

Replete ATP

Severe ATP depletion

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