Sickle Cell Disease

L.W. Statius van Eps

Herrick [1] was the first to discover sickle cell hemoglobin (a 2 pS2) with sickle-shaped erythrocytes. In 1910, he described the case of a young black student from the West Indies with severe anemia characterized by "peculiar elongated and sickle-shaped red blood corpuscles." Herrick also noted a slightly increased volume of urine of low specific gravity and thus observed the most frequent feature of sickle cell nephropathy: inability of the kidney to concentrate urine normally.

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