Signs And Symptoms Of Toxic Effects Of Lithium

Toxic Effect

Plasma Lithium Level

Signs and Symptoms

Mild

1-1.5 mmol/L

Impaired concentration, lethargy, irritability, muscle weakness, tremor, slurred speech, nausea

Moderate

1.6-2.5 mmol/L

Disorientation, confusion, drowsiness, restlessness, unsteady gait, coarse tremor, dysarthria, muscle fasciculation, vomiting

Severe

>2.5 mmol/L

Impaired consciousness (with progression to coma), delirium, ataxia, generalized fasciculations, extrapyramidal symptoms, convulsions, impaired renal function

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