Steven J Scheinman

A variety of metabolic conditions produce disease of the renal interstitium and tubular epithelium. In many cases, disease reflects the unique functional features of the nephron, in which the ionic composition, pH, and concentration of both the tubular and interstitial fluid range widely beyond the narrow confines seen in other tissues. Recent genetic discoveries have offered new insights into the molecular basis of some of these conditions, and have raised new questions. This chapter discusses nephrocalcinosis, the relatively nonspecific result of a variety of hypercalcemic and hypercalciuric states, as well as the renal consequences of hyperox-aluria, hypokalemia, and hyperuricemia.

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