Tacrolimus

Major advantages of tacrolimus

Major disadvantages of tacrolimus

Steroid sparing

Increased viral infections

Less hypertension

Cytomegalovirus

Rescue of cyclosporine-resistant

Epstein-Barr virus

rejections

Increased lymphoproliferative disease

Minor advantages of tacrolimus

Minor disadvantages of tacrolimus

Better graft survival

Increased acute rejection?

Less hirsutism

More diabetogenic?

Less gingival hypertrophy

Hyperkalemia?

Less neurologic dysfunction

Hypomagnesemia?

Less metabolic acidosis

Similarities of tacrolimus and

Less hyperlipidemia

cyclosporine

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