Vasodilators Used In Experimental Acute Renal Failure

Vasodilator

ARF Disorder

Time Given in Relation to Induction

Observed Effect

Propranolol

Ischemic

Before, during, after

¿Scr, BUN if given before,

during; no effect if given after

Phenoxybenzamine

Toxic

Before, during, after

Prevented fall in RBF

Clonidine

Ischemic

After

¿Scr, BUN

Bradykinin

Ischemic

Before, during

TRBF, GFR

Acetylcholine

Ischemic

Before, after

TRBF; no change in GFR

Prostaglandin E-|

Ischemic

After

TRBF; no change in GFR

Prostaglandin E2

Ischemic, toxic

Before, during

TGFR

Prostaglandin I2

Ischemic

Before, during, after

TGFR

Saralasin

Toxic, ischemic

Before

TRBF; no change in Scr, BUN

Captopril

Toxic, ischemic

Before

TRBF; no change in Scr, BUN

Verapamil

Ischemic, toxic

Before, during, after

TRBF, GFR in most studies

Nifedipine

Ischemic

Before

Tgfr

Nitrendipine

Toxic

Before, during

Tgfr

Diliazem

Toxic

Before, during, after

TGFR; ¿recovery time

Chlorpromazine

Toxic

Before

TGFR; ¿recovery time

Atrial natriuretic

Ischemic, toxic

After

TRBF, GFR

peptide peptide

BUN—blood urea nitrogen; GFR—glomerular filtration rate; RBF—renal blood flow; Scr-serum creatinine.

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