Clinical Use of Growth Factors in Acute Renal Failure

FIGURE 17-17

Body weights of rats with ischemic acute renal failure (ARF) treated with insulin-like growth factor (IGF-I) or vehicle. Unlike epidermal growth factor or hepatocyte growth factor (HGF), IGF-I is anabolic even in the setting of acute renal injury. These data are from the experiment described in Figure 17-16. As the data in this figure demonstrate, ARF is a highly catabolic state: vehicle-treated animals experience 15% weight reduction. Animals that received IGF-I experienced only a 5% reduction in body weight and were back to baseline by 7 days. Data are expressed as mean ± standard error. Significant differences between groups are indicated by asterisks. (From Miller et al. [2]; with permission.)

FIGURE 17-18

Photomicrograph of kidneys from rats with acute renal failure (ARF) treated with insulin-like growth factor (IGF-I) or vehicle. These photomicrographs are of histologic sections stained with hematoxylin and eosin originating from kidneys of rats that received vehicle or IGF 1 after ischemic renal injury. Kidneys were obtained 7 days after the insult. There is evidence of considerable residual injury in the kidney from the vehicle-treated rat (A): dilation and simplification of tubules, interstitial calcifi

cations, and papillary proliferations the tubule lumen of proximal tubules. The kidney obtained from the IGF-I-treated rat (B) appears almost normal, showing evidence of regeneration and restoration of normal renal architecture. In this experiment the histologic appearance of kidneys from the IGF-I-treated animals was statistically better than that of the vehicle-treated controls, as determined by a pathologist blinded to therapy. (From Miller et al. [2]; with permission.)

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