Leukocytes in Acute Renal Failure

Inactive leukocyte

Leukocyte adhesion molecules

Endothelial adhesion molecules htt ICAM

A. Ligand for leukocyte selections

Inactive leukocyte

Endothelial adhesion molecules htt ICAM

A. Ligand for leukocyte selections

Selection-mediated rolling of leukocytes

Firm adhesion of leukocytes (integrin-mediated)

Selection-mediated rolling of leukocytes

Firm adhesion of leukocytes (integrin-mediated)

Diapedesis

Diapedesis

Tissue injury

Release of oxidants proteases elastases

FIGURE 14-30

Role of adhesion molecules in mediating leukocyte attachment to endothelium. A, The normal inflammatory response is mediated by the release of cytokines that induce leukocyte chemotaxis and activation. The initial interaction of leukocytes with endothelium is mediated by the selectins and their ligands both of which are present on leukocytes and endothelial cells,

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