Schizophrenic Patients

The Dopaminergic Pathways

Dopaminergic Pathways And Antipsychotics

Figure 4.6 Representation of the primary dopamine-containing tracts in the human brain. The nigrostriatal tract is primarily involved in motor control, but also in reward- and goal-directed behavior. Blockade of D2 receptors here produces some of the antipsychotic effects of antipsychotics, but high levels of blockade gt 80 produce parkinsonian side-effects. Blockade of D2 receptors in the tuberoinfundibular pathway increases plasma prolactin. It is thought that it is the blockade of D2 and...