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Figure 4.7 Dopamine is synthesized in a common pathway with norepinephrine. In the pathway shown, tyrosine hydroxylase is the rate-limiting enzyme. Dopamine ß-hydroxylase is only found in noradrenaline neurons in the CNS

Figure 4.8 Dopamine is metabolized by two enzymes. One, monoamine oxidase type B (MAO-B), is intraneuronal, and the other, catechol-O-methyl transferase (COMT), is extraneuronal. The primary metabolite of dopamine is homovanillic acid

Dopamine is synthesized as part of the common pathway for catecholamines (Figure 4.7). Dopamine is metabolized by two enzymes; one, monoamine oxidase type B (MAO-B), is intraneuronal, and the other, catechol-O-methyl transferase (COMT), is extraneuronal. The primary metabolite of dopamine is homovanillic acid (HVA; Figure 4.8).

Serotonin

The serotonergic hypothesis of schizophrenia predates the dopaminergic hypothesis and stems from the finding by Woolley and Shaw in 195412 that the hallucinogen LSD acted via serotonin.

Figure 4.8 Dopamine is metabolized by two enzymes. One, monoamine oxidase type B (MAO-B), is intraneuronal, and the other, catechol-O-methyl transferase (COMT), is extraneuronal. The primary metabolite of dopamine is homovanillic acid

Extraneuronal Intraneuronal

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