1. Dodd J, Castellucci VF (1991) Smell and taste: The chemical senses. Principles of neural sciences. In: Kandel ER, Schwartz JH, Jessel TM (eds) Elsevier Science Publishing Co, New York, p 512-529

2. Turner BH, Mishkin M, Knapp M (1980) Organization of the amygdalope-

tal projections from modality-specific cortical association areas in the monkey. J Comp Neurol 191: 515-543 Herz RS (2000) Scents of time. The Sciences 34-39

Zatorre RJ et al (1992) Functional localization and lateralization of human olfactory cortex. Nature 360: 339-340

Doty RL et al (1978) Intranasal trigeminal stimulation from odorous volatiles: psychometric responses from anosmic and normal humans. Physiol Behav 20: 175-185

Hummel T et al (2003) Effects of olfactory function, age, and gender on tri-geminally mediated sensations: a study based on the lateralization of chemo-sensory stimuli. Toxicol Lett 140-141: 273-280

Hummel T (2000) Assessment of intranasal trigeminal function. Int J Psy-chophysiol 36: 147-155

Cain WS (1974) Contribution of the trigeminal nerve to perceived odor magnitude. Ann NY Acad Sci 237: 28-34

Cain WS, Murphy CL (1980) Interaction between chemoreceptive modalities of odour and irritation. Nature 284: 255-257

Hummel T et al (1996) Loss of olfactory function leads to a decrease of trigeminal sensitivity. Chem Senses 21: 75-79

Gudziol H, Schubert M, Hummel T (2001) Decreased trigeminal sensitivity in anosmia. ORL J Otorhinolaryngol Relat Spec 63: 72-75 Krause F (1895) Die Physiologie des Trigeminus nach Untersuchungen an Menschen, bei denen das Ganglion Gasseri entfernt worden ist (Schluss). Munch Med Wochenschr 27: 628-631

Ikeda I (1909) On a new seasoning. J Tokyo Chem Soc 30: 820-836 Ikeda K (2002) New seasonings. Chem Senses 27: 847-849 Chaudhari N, Landin AM, Roper SD (2000) A metabotropic glutamate receptor variant functions as a taste receptor. Nat Neurosci 3: 113-119 Witt M, Reutter K, Miller IJ Jr (2003) Morphology of the peripheral taste system. Handbook of olfaction and gustation. In: Doty RL (ed) Marcel Dekker, Inc, New York, p 651-678

Beidler LM, Smallman RL (1965) Renewal of cells within taste buds. J Cell Bio 27: 263-272

Jacobson L, Trotier D, Doving KB (1998) Anatomical description of a new organ in the nose of domesticated animals by Ludvig Jacobson (1813). Chem Senses 23: 743-754

Cuvier G (1811) Rapport - Fait a l'Institut, sur un Memoire de M. Jacob-son, intitule: Descripion anatomique d'un organe observe dans les mammiferes. Annales du Museum d'Histoire Naturelle Paris. Tome 18: 412-424 Karlson P, Lüscher M (1959) "Pheromones": a new term for a class of biologically active substances. Nature 183: 55-56

Schaal B et al (2003) Chemical and behavioural characterization of the rabbit mammary pheromone. Nature 424: 68-72

Dorries KM, Adkins-Regan E, Halpern BP (1997) Sensitivity and behavioral responses to the pheromone androstenone are not mediated by the vomero-nasal organ in domestic pigs. Brain Behav Evol 49: 53-62

23. Monti-Bloch L, Grosser BI (1991) Effect of putative pheromones on the electrical activity of the human vomeronasal organ and olfactory epithelium. J Steroid Biochem Molec Biol 39: 573-582

24. Witt M et al (2002) On the chemosensory nature of the vomeronasal epithelium in adult humans. Histochem Cell Biol 117: 493-509

25. Knecht M et al (2001) Frequency and localization of the putative vomer-onasal organ in humans in relation to age and gender. Laryngoscope 111: 448-452

26. Witt M et al (2000) Characterization of the adult human vomeronasal organ using immunohistochemical and electrophysiological measures. Chem Senses 25: 668

27. Knecht M et al (2003) Assessment of olfactory function and androstenone odor thresholds in humans with or without functional occlusion of the vomeronasal duct. Behav Neurosci 117: 1135-1141

28. Stern K, McClintock MK (1998) Regulation of ovulation by human pheromones. Nature 392: 177-179

29. Savic I et al (2001) Smelling of odorous sex hormone-like compounds causes sex-differentiated hypothalamic activations in humans. Neuron 31: 661-668

30. Rodriguez I et al (2000) A putative pheromone receptor gene expressed in human olfactory mucosa. Nat Genet 26: 18-19

31. Mozell MM (1964) Evidence for sorption as a mechanism of the olfactory analysis of vapours. Nature 203: 1181-1182

32. Mozell MM, Jagodowicz M (1973) Chromatographic separation of odorants by the nose: retention times measured across in vivo olfactory mucosa. Science 181: 1247-1249

33. Sobel N et al (1999) The world smells different to each nostril. Nature 402: 35

34. Amoore JE (1967) Specific anosmia: a clue to the olfactory code. Nature 214: 1095-1098

35. Henning H (1916) Der Geruch. Johann Ambrosius Barth, Leipzig

36. Dyson GM (1938) The scientific basis of odour. Chem Ind 57: 647-651

37. Turin L (1996) A spectroscopic mechanism for primary olfactory reception. Chem Senses 21: 773-791

38. Keller A, Vosshall LB (2004) A psychophysical test of the vibration theory of olfaction. Nat Neurosci 7: 337-338

39. Buck L, Axel R (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65: 175-187

40. Gilad Y et al (2003) Human specific loss of olfactory receptor genes. Proc Natl Acad Sci USA 28: 28

41. Menashe I et al (2003) Different noses for different people. Nat Genet 34: 143-144

42. Gilad Y et al (2003) Natural selection on the olfactory receptor gene family in humans and chimpanzees. Am J Hum Genet 73: 489-501

43. Gilad Y et al (2004) Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primates. PLoS Biol 2: E5

Man O, Gilad Y, Lancet D (2004) Prediction of the odorant binding site of olfactory receptor proteins by human-mouse comparisons. Protein Sci 13: 240-254

Strotmann J et al (1994) Olfactory neurones expressing distinct odorant receptor subtypes are spatially segregated in the nasal neuroepithelium. Cell Tissue Res 276: 429-438

Vassar R, Ngai J, Axel R (1993) Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell 74: 309-318 Ressler KJ, Sullivan SL, Buck LB (1993) A zonal organization of odorant receptor gene expression in the olfactory epithelium. Cell 73: 597-609 Vassar R et al (1994) Topographic organization of sensory projections to the olfactory bulb. Cell 79: 981-991

Nef P et al (1992) Spatial pattern of receptor expression in the olfactory epithelium. Proc Natl Acad Sci USA 89: 8948-8952

Mombaerts P et al (1996) Visualizing an olfactory sensory map. Cell 87: 675-686

Zhao H et al (1998) Functional expression of a mammalian odorant receptor. Science 279: 237-242

Araneda RC, Kini AD, Firestein S (2000) The molecular receptive range of an odorant receptor. Nat Neurosci 3: 1248-1255

Uchida N et al (2000) Odor maps in the mammalian olfactory bulb: domain organization and odorant structural features. Nat Neurosci 3: 1035-1043 Malnic B et al (1999) Combinatorial receptor codes for odors. Cell 96: 713723

Landis BN et al (2003) Ratings of overall olfactory function. Chem Senses 28: 691-694

Hummel T et al (2001) Screening of olfactory function with a four-minute odor identification test: reliability, normative data, and investigations in patients with olfactory loss. Ann Otol Rhinol Laryngol 110: 976-981

Doty RL, Shaman P, Dann M (1984) Development of the University of

Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol Behav 32: 489-502

Cain WS et al (1988) Evaluation of olfactory dysfunction in the Connecticut

Chemosensory Clinical Research Center. Laryngoscope 98: 83-88

Doty RL et al (1984) University of Pennsylvania Smell Identification Test:

a rapid quantitative olfactory function test for the clinic. Laryngoscope 94:


Kobal G et al (1996) ''Sniffin' sticks'': screening of olfactory performance. Rhinology 34: 222-226

Hummel T et al (1997) 'Sniffin' sticks': olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses 22: 39-52

Kobal G et al (2000) Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, and olfactory thresholds. Eur Arch Otorhinolaryngol 257: 205-211

63. Kondo H et al (1998) A study of the relationship between the T&T olfactometer and the University of Pennsylvania Smell Identification Test in a Japanese population. Am J Rhinol 12: 353-358

64. Lecanu JB et al (2002) Valeurs normatives du test olfactometrique Biolfa. Ann Otolaryngol Chir Cervicofac 119: 164-169

65. Briner HR, Simmen D (1999) Smell diskettes as screening test of olfaction. Rhinology 37: 145-148

66. Ho WK et al (2002) Change in olfaction after radiotherapy for nasopharyngeal cancer - a prospective study. Am J Otolaryngol 23: 209-214

67. Lotsch J, Lange C, Hummel T (2004) A simple and reliable method for clinical assessment of odor thresholds. Chem Senses 29: 311-317

68. Linschoten MR et al (2001) Fast and accurate measurement of taste and smell thresholds using a maximum-likelihood adaptive staircase procedure. Percept Psychophys 63: 1330-1347

69. Hawkes CH, Shephard BC (1993) Selective anosmia in Parkinson's disease? Lancet 341: 435-436

70. Koss E et al (1987) Olfactory detection and recognition in Alzheimer's disease. Lancet 1: 622

71. Koss E et al (1988) Olfactory detection and identification performance are dissociated in early Alzheimer's disease. Neurology 38: 1228-1232

72. Frasnelli JA et al (2002) Olfactory function in chronic renal failure. Am J Rhinol 16: 275-279

73. Hornung DE et al (1998) The olfactory loss that accompanies an HIV infection. Physiol Behav 15: 549-556

74. Jones-Gotman M, Zatorre RJ (1988) Olfactory identification deficits in patients with focal cerebral excision. Neuropsychologia 26: 387-400

75. Mesholam RI et al (1998) Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases. Arch Neurol 55: 84-90

76. Daum RF et al (2000) Riechprüfung mit "Sniffin' Sticks'' zur klinischen Diagnostik des Morbus Parkinson. Nervenarzt 71: 643-650

77. Klimek L et al (1998) Lateralized and bilateral olfactory function in patients with chronic sinusitis compared with healthy control subjects. Laryngoscope 108: 111-114

78. Ottoson D (1956) Analysis of the electrical activity of the olfactory epithelium. Acta Physiol Scand 35: 1-83

79. Hummel T, Knecht M, Kobal G (1996) Peripherally obtained electrophy-siological responses to olfactory stimulation in man: electro-olfactograms exhibit a smaller degree of desensitization compared with subjective intensity estimates. Brain Res 717: 160-164

80. Leopold DA et al (2000) Anterior distribution of human olfactory epithelium. Laryngoscope 110: 417-421

81. Wang L, Chen L, Jacob T (2004) Evidence for peripheral plasticity in human odour response. J Physiol 554: 236-244

82. Spehr M et al (2004) The HOR17-4 signalling system - one receptor, dual capacity. Chem Sens (in press)

83. Rawson NE et al (1995) Functionally mature olfactory receptor neurons from two anosmic patients with Kallmann syndrome. Brain Res 681: 5864

84. Hummel T, Mojet J, Kobal G (1997) Electro-olfactograms are present when odorous stimuli have not been perceived. Chem Senses 22: 196

85. Knecht M, Hummel T (2004) Recording of the human electro-olfactogram. Physiol Behav 83: 13-19

86. Picton TW, Hillyard SA (1988) Endogenous event-related potentials. EEG-handbook, revised series, vol. 3. In: Picton TW (ed) Elsevier, Amsterdam, p 361-426

87. Kobal G, Plattig KH (1978) Methodische Anmerkungen zur Gewinnung olfaktorischer EEG-Antworten des wachen Menschen (objektive Olfaktometrie). Z EEG-EMG 9: 135-145

88. Kobal G (1981) Elektrophysiologische Untersuchungen des menschlichen Geruchssinns. Thieme Verlag, Stuttgart

89. Kobal G, Hummel T (1991) Olfactory evoked potentials in humans. Smell and taste in health and disease. In: Getchell TV et al (eds) Raven Press, New York, p 255-275

90. Pause BM et al (1996) The nature of the late positive complex within the olfactory event-related potential. Psychophysiology 33: 168-172

91. Krauel K et al (1998) Attentional modulation of central odor processing. Chem Senses 23: 423-432

92. Donchin E et al (1986) Cognitive psychophysiology and human information processing. Psychophysiology: systems, processes and applications. In: Coles MGH, Donchin E, Porges SW (eds) Guilford Press, New York

93. Kobal G, Hummel T, Van Toller S (1992) Differences in chemosensory evoked potentials to olfactory and somatosensory chemical stimuli presented to left and right nostrils. Chem Senses 17: 233-244

94. Pause B, Sojka B, Ferstl R (1996) The latency but not the amplitude of the olfactory event-related potential (OERP) varies with the odor concentration. Chem Senses 21: 485

95. Murphy C et al (1998) Age effects on central nervous system activity reflected in the olfactory event-related potential. Evidence for decline in middle age. Ann NY Acad Sci 855: 598-607

96. Lorig TS et al (1996) The effects of active and passive stimulation on chemosensory event-related potentials. Int J Psychophysiol 23: 199-205

97. Williamson SJ, Kaufman L (1987) Analysis of neuromagnetic signals. Handbook of electroencephalography and clinical neurophysiologgy, volume 1, Methods of brain electrical and magnetical signals. In: Gevins AS, Remond AA (eds) Elsevier, Amsterdam, p 405-448

98. Huttunen J et al (1986) Cortical responses to painful CO2-stimulation of nasal mucosa: a magnetencephalographic study in man. Electroenceph Clin Neurophysiol 64: 347-349

99. Kettenmann B et al (1996) Magnetoencephalographical recordings: separation of cortical responses to different chemical stimulation in man. Funct Neurosci [EEG Suppl] 46: 287-290

Kettenmann B et al (1997) Multiple olfactory activity in the human neocortex identified by magnetic source imaging. Chem Senses 22: 493-502 Ayabe-Kanamura S et al (1997) Measurement of olfactory evoked magnetic fields by a 64-channel whole-head SQUID system. Chem Senses 22: 214215

Welge-Lussen A (1999) Chemosensorisch evozierte Potentiale - Anwendung und Bedeutung im klinischen Alltag. HNO 47: 453-455 Kobal G, Hummel T (1998) Olfactory and intranasal trigeminal event-related potentials in anosmic patients. Laryngoscope 108: 1033-1035 Peters JM et al (2003) Olfactory function in mild cognitive impairment and Alzheimer's disease: an investigation using psychophysical and electrophysiological techniques. Am J Psychiatry 160: 1995-2002 Hudry J et al (2003) Olfactory short-term memory and related amygdala recordings in patients with temporal lobe epilepsy. Brain 126: 1851-1863 Savic I (2002) Imaging of brain activation by odorants in humans. Curr Opin Neurobiol 12: 455-461

Zald DH, Pardo JV (2000) Functional neuroimaging of the olfactory system in humans. Int J Psychophysiol 36: 165-181

Kettenmann B, Hummel T, Kobal G (2001) Functional imaging of olfactory activation in the human brain. Methods and frontiers in chemosensory research. In: Simon SA, Nicolelis MAL (eds) CRC Press, Baco Raton, Florida, USA, p 477-506

Small DM et al (1997) Flavor processing: more than the sum of its parts. Neuroreport 8: 3913-3917

Kareken DA et al (2004) Olfactory system activation from sniffing: effects in piriform and orbitofrontal cortex. Neuroimage 22: 456-465 Savic I, Berglund H (2004) Passive perception of odors and semantic circuits. Hum Brain Mapp 21: 271-278

Sobel N et al (2000) Time course of odorant-induced activation in the human primary olfactory cortex. J Neurophysiol 83: 537-551 Poellinger A et al (2001) Activation and habituation in olfaction - an fMRI study. Neuroimage 13: 547-560

Anderson AK et al (2003) Dissociated neural representations of intensity and valence in human olfaction. Nat Neurosci 6: 196-202 Yousem DM et al (1999) The effect of age on odor-stimulated functional MR imaging. Am J Neuroradiol 20: 600-608

Henkin RI, Levy LM, Lin CS (2000) Taste and smell phantoms revealed by brain functional MRI (fMRI). J Comput Assist Tomogr 24: 106-123 Wysocki CJ, Gilbert AN (1989) National Geographic Smell Survey: effects of age are heterogenous. Ann NY Acad Sci 561: 12-28 Hoffman HJ, Ishii EK, MacTurk RH (1998) Age-related changes in the prevalence of smell/taste problems among the United States adult population. Results of the 1994 disability supplement to the National Health Interview Survey (NHIS). Ann NY Acad Sci 855: 716-722 Doty RL et al (1984) Smell identification ability: changes with age. Science 226: 1441-1443

Murphy C et al (2002) Prevalence of olfactory impairment in older adults. JAMA 288: 2307-2312

Bramerson A et al (2004) Prevalence of olfactory dysfunction: the skovde population-based study. Laryngoscope 114: 733-737

Landis BN, Konnerth CG, Hummel T (2004) A study on the frequency of olfactory dysfunction. Laryngoscope 114: 1764-1769 Miwa T et al (2001) Impact of olfactory impairment on quality of life and disability. Arch Otolaryngol Head Neck Surg 127: 497-503 Temmel AF et al (2002) Characteristics of olfactory disorders in relation to major causes of olfactory loss. Arch Otolaryngol Head Neck Surg 128: 635641

Hummel T, Nordin S (2004) Olfactory disorders and their consequences for quality of life - A review. Acta Oto-Laryngologica, in press

Santos DV et al (2004) Hazardous events associated with impaired olfactory function. Arch Otolaryngol Head Neck Surg 130: 317-319

Damm M et al (2004) Riechstörungen - Epidemiologie und Therapie in

Deutschland, (Österreich und der Schweiz. HNO 52: 112-120

Quint C et al (2001) Patterns of non-conductive olfactory disorders in eastern

Austria: a study of 120 patients from the Department of Otorhinolaryngol-

ogy at the University of Vienna. Wien Klin Wochenschr 113: 52-57

Seiden AM, Duncan HJ (2001) The diagnosis of a conductive olfactory loss.

Laryngoscope 111: 9-14

Deems DA et al (1991) Smell and taste disorders: a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otorhino-laryngol Head Neck Surg 117: 519-528

Jafek BW et al (1990) Postviral olfactory dysfunction. Am J Rhinol 4: 91100

Sugiura M et al (1998) An epidemiological study of postviral olfactory disorder. Acta Otolaryngol [Suppl] 538: 191-196

Faulcon P et al (1996) Anosmie secondaire a une rhinite aigue: semiologie et evolution a propos d'une serie de 118 patients. Ann Otolaryngol Chir Cervi-cofac 116: 351-357

Duncan HJ, Seiden AM (1995) Long-term follow-up of olfactory loss secondary to head trauma and upper respiratory tract infection. Arch Otolary-ngol Head Neck Surg 121: 1183-1187

Quint C et al (2002) The quinoxaline derivative caroverine in the treatment of sensorineural smell disorders: a proof-of-concept study. Acta Otolaryngol 122: 877-881

Hummel T, Heilmann S, Huttenbrink KB (2002) Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract. Laryngoscope 112: 2076-2080

Dhong HJ, Chung SK, Doty RL (1999) Estrogen protects against 3-methylindole-induced olfactory loss. Brain Res 824: 312-315 Hughes LF et al (2002) Effects of hormone replacement therapy on olfac4-tory sensitivity: cross-sectional and longitudinal studies. Climacteric 5: 140150

Portier F et al (2000) Semiologie, etiologie et evolution des parosmies: a propos de 84 cas. Ann Otolaryngol Chir Cervicofac 117: 12-18 Frasnelli J, Hummel T (2004) Olfactory dysfunction and daily life. Eur Arch Otorhinolaryngol 5: 5

Legg JW (1873) A case of anosmia following a blow. Lancet 2: 659-660 Yousem DM et al (1999) Posttraumatic smell loss: relationship of psycho-physical tests and volumes of the olfactory bulbs and tracts and the temporal lobes. Acad Radiol 6: 264-272

Zusho H (1982) Posttraumatic anosmia. Arch Otolaryngol 108: 90-92 Frank Greiffenstein M, John Baker W, Gola T (2002) Brief report: anosmia and remote outcome in closed head injury. J Clin Exp Neuropsychol 24: 705-709

Sumner D (1964) Post-traumatic anosmia. Brain 87: 107-120

Delank KW, Fechner G (1996) Zur Pathophysiologie der posttraumatischen

Riechstorungen. Laryngorhinootologie 75: 154-159

Fein BT, Kamin PB, Fein NN (1966) The loss of sense of smell in nasal allergy. Ann Allergy 24: 278-283

Doty RL (1997) Olfaction. Nasal Polyposis - An inflammatory disease and its treatement. In: Mygind N, Lildholdt T (eds) Munksgaard, Copenhagen, p 153-159

Landis BN et al (2003) Retronasal olfactory function in nasal polyposis. Laryngoscope 113: 1993-1997

Hotchkiss WT (1956) Influence of Prednisone on nasal polyposis with anosmia. Arch Otolaryngol 64: 478-479

Klimek L et al (1997) Olfactory function after microscopic endonasal surgery in patients with nasal polyps. Am J Rhinol 11: 251-255 Apter AJ et al (1995) Allergic rhinitis and olfactory loss. Ann Allergy Asthma Immunol 75: 311-316

Stuck BA et al (2003) Mometasone furoate nasal spray improves olfactory performance in seasonal allergic rhinitis. Allergy 58: 1195 Ansari KA, Johnson A (1975) Olfactory function in patients with Parkinson's disease. J Chron Dis 28: 493-497

Ward CD, Hess WA, Calne DB (1983) Olfactory impairment in Parkinson's disease. Neurology 33: 943-946

Doty RL, Deems D, Steller S (1988) Olfactory dysfunction in Parkinson's disease: A general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology 38: 1237-1244

Sobel N et al (2001) An impairment in sniffing contributes to the olfactory impairment in Parkinson's disease. Proc Natl Acad Sci USA 98: 4154-4159 Barz S et al (1997) Chemosensory event-related potentials in response to tri-geminal and olfactory stimulation in idiopathic Parkinson's disease. Neurology 49: 1424-1431

Hawkes CH, Shephard BC (1998) Olfactory evoked responses and identification tests in neurological disease. Ann NY Acad Sci 855: 608-615 Hawkes CH, Shephard BC, Daniel SE (1999) Is Parkinson's disease a primary olfactory disorder? QJM 92: 473-480

Hawkes C (2003) Olfaction in neurodegenerative disorder. Mov Disord 18: 364-372

Berendse HW et al (2001) Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patients' relatives with a decreased sense of smell. Ann Neurol 50: 34-41

Sommer U et al (2004) Detection of presymptomatic Parkinson's disease: combination of olfactory tests, transcranial sonography, and 123 I-FP-CIT-SPECT. Mov Disord, in press

Muller A et al (2002) Olfactory function in idiopathic Parkinson's disease (IPD): results from cross-sectional studies in IPD patients and long-term follow-up of de-novo IPD patients. J Neural Transm 109: 805-811 Heilmann S, Huettenbrink KB, Hummel T (2004) Local and systemic administration of corticosteroids in the treatment of olfactory loss. Am J Rhi-nol 18: 29-33

Jorgensen MB, Buch NH (1961) Studies on the sense of smell and taste in diabetics. Arch Otolaryngol 53: 539-545

Weinstock RS, Wright HN, Smith DU (1993) Olfactory dysfunction in diabetes mellitus. Physiol Behav 53: 17-21

Le Floch JP et al (1993) Smell dysfunction and related factors in diabetic patients. Diabetes Care 16: 934-937

Doty RL (1986) Gender and endocrine-related influences on human olfactory perception. Clinical Measurement of Taste and Smell. In: Meiselman R (ed) MacMillan, New York, p 377-413

McConnell RJ et al (1975) Defects of taste and smell in patients with hypo-thyroidism. Am J Med 59: 354-364

Henkin RI, Bartter FC (1966) Studies on olfactory thresholds in normal man and in patients with adrenal cortical insufficiency: the role of adrenal cortical steroids and of serum sodium concentration. J Clin Invest 45: 1631-1639

Schiffman SS (1983) Taste and smell in disease (first of two parts). N Engl J Med 308: 1275-1279

Campanella G, Filla A, De Michele G (1978) Smell and taste acuity in epileptic syndromes. Eur Neurol 17: 136-141

Eskenazi B et al (1986) Odor perception in temporal lobe epilepsy patients with and without temporal lobectomy. Neuropsychologia p 553-562 Jones-Gotman M et al (1997) Contribution of medial versus lateral temporal-lobe structures to human odour identification. Brain 120: 18451856

Kohler CG et al (2001) Olfactory dysfunction in schizophrenia and temporal lobe epilepsy. Neuropsychiatry Neuropsychol Behav Neurol 14: 83-88 Hummel T et al (1995) Chemosensory event-related potentials in patients with temporal lobe epilepsy. Epilepsia 36: 79-85

Schiffman SS (1983) Taste and smell in disease (second of two parts). N Engl J Med 308: 1337-1343

Henkin RI, Smith FR (1971) Hyposmia in acute viral hepatitis. Lancet 1: 823-826

Kleinschmidt EG, Kramp B, Schwager A (1976) Functional study on the sense of smell in patients with chronic liver disease. Z Gesamte Inn Med 31: 853-856

Reaich D (1997) Odour perception in chronic renal disease. Lancet 350: 1191 Adelman BT (1995) Altered taste and smell after anesthesia: cause and effect? Anesthesiology 83: 647-649

Kimmelman CP (1994) The risk to olfaction from nasal surgery. Laryngoscope 104: 981-988

Damm M et al (2003) Olfactory changes at threshold and suprathreshold levels following septoplasty with partial inferior turbinectomy. Ann Otol Rhinol Laryngol 112: 91-97

Briner HR, Simmen D, Jones N (2003) Impaired sense of smell in patients with nasal surgery. Clin Otolaryngol 28: 417-419

Hastings L, Miller ML (1997) Olfactory loss to toxic exposure. Taste and smell disorders. In: Seiden AM (ed) Thieme, New York, p 88-106 Doty RL et al (2003) Influences of antihypertensive and antihyperlipidemic drugs on the senses of taste and smell: a review. J Hypertens 21: 1805-1813 Kharoubi S (2003) Anosmie toxi-medicamenteuse a la nifedipine. Presse Med 32: 1269-1272

Levenson JL, Kennedy K (1985) Dysosmia, dysgeusia, and nifedipine. Ann Intern Med 102: 135-136

Welge-Luessen A, Wolfensberger M (2003) Reversible anosmia after amikacin therapy. Arch Otolaryngol Head Neck Surg 129: 1331-1333 Jafek BW et al (1990) Congenital anosmia. Ear Nose Throat J 69: 331-337 Abolmaali ND et al (2002) MR evaluation in patients with isolated anosmia since birth or early childhood. AJNR Am J Neuroradiol 23: 157-164 Yousem DM et al (1996) MR evaluation of patients with congenital hypo-smia or anosmia. Am J Radiol 166: 439-443

Kallmann FJ, Schoenfeld WA, Barrera SE (1944) The genetic aspects of primary eunuchoidism. Am J Ment Defic 48: 203-236

Wustenberg EG et al (2001) Normosmie bei Kallmann Syndrom - Ein Fallbericht. Laryngorhinootologie 80: 85-89

Amoore JE (1991) Specific anosmias. Smell and taste in health and disease. In: Getchell TV et al (eds) Raven Press, New York, p 655-664 Kaufman MD, Lassiter KR, Shenoy BV (1988) Paroxysmal unilateral dysosmia: a cured patient. Ann Neurol 24: 450-451

Lanza DC, Kennedy DW (1997) Adult rhinosinusitis defined. Otolaryngol Head Neck Surg 117: S1-7

Togias A (1999) Mechanisms of nose-lung interaction. Allergy 54[Suppl] 57: 94-105

Stevens CN, Stevens MH (1985) Quantitative effects of nasal surgery on olfaction. Am J Otolaryngol 6: 264-267

Haddad FS et al (1985) Intracranial complications of submucous resection of the nasal septum. Am J Otolaryngol 6: 443-447

Gross-Isseroff R et al (1989) Olfactory function following late repair of choanal atresia. Laryngoscope 99: 1165-1166

203. Hosemann W et al (1993) Olfaction after endoscopic endonasal ethmoidec-tomy. Am J Rhinology 7: 11-15

204. Rowe-Jones JM, Mackay IS (1997) A prospective study of olfaction following endoscopic sinus surgery with adjuvant medical treatment. Clin Otolary-ngol 22: 377-381

205. Downey LL, Jacobs JB, Lebowitz RA (1996) Anosmia and chronic sinus disease. Otolaryngol Head Neck Surg 115: 24-28

206. Min YG et al (1995) Recovery of nasal physiology after functional endo-scopic sinus surgery: olfaction and mucociliary transport. ORL J Otorhino-laryngol Relat Spec 57: 264-268

207. Lee SH et al (2000) Olfactory mucosal findings in patients with persistent anosmia after endoscopic sinus surgery. Ann Otol Rhinol Laryngol 109: 720-725

208. Jafek BW, Murrow B, Johnson EW (1994) Olfaction and endoscopic sinus surgery. Ear Nose Throat J 73: 548-552

209. Passagia JG et al (1999) Surgical approaches to the anterior fossa, and preservation of olfaction. Adv Tech Stand Neurosurg 25: 195-241

210. Spetzler RF et al (1993) Preservation of olfaction in anterior craniofacial approaches. J Neurosurg 79: 48-52

211. Suzuki J, Yoshimoto T, Mizoi K (1981) Preservation of the olfactory tract in bifrontal craniotomy for anterior communicating artery aneurysms, and the functional prognosis. J Neurosurg 54: 342-345

212. Dulguerov P, Allal AS, Calcaterra TC (2001) Esthesioneuroblastoma: a meta-analysis and review. Lancet Oncol 2: 683-690

213. Dias FL et al (2003) Patterns of failure and outcome in esthesioneuroblas-toma. Arch Otolaryngol Head Neck Surg 129: 1186-1192

214. Bakay L, Cares HL (1972) Olfactory meningiomas. Report on a series of twenty-five cases. Acta Neurochir (Wien) 26: 1-12

215. Welge-Luessen A et al (2001) Olfactory function in patients with olfactory groove meningioma. J Neurol Neurosurg Psychiatry 70: 218-221

216. Bonfils P, Corre FL, Biacabe B (1999) Semiologie et etiologie des anosmies: a propos de 306 patients. Ann Otolaryngol Chir Cervicofac 116: 198-206

217. Costanzo RM, DiNardo LJ, Zasler ND (1995) Head injury and olfaction. Handbook of Olfaction and Gustation. In: Doty RL (ed) Marcel Dekker, New York, p 493-502

218. Murphy C, Doty RL, Duncan HJ (2003) Clinical disorders of olfaction. Handbook of olfaction and gustation. In: Doty RL (ed) Marcel Dekker, New York, p 461-478

219. Gradziadei PPC, Monti-Graziadei GA (1978) Continuous nerve cell renewal in the olfactory system. Handbook of sensory physiology, vol. IX. In: Jacob-son M (ed) Springer, Wien, New York, p 55

220. Hummel T et al (2004) Qualitative olfactory dysfunction: frequency and prognostic significance. Abstractbook AchemS p 89 (Poster 339)

221. Leopold DA et al (1991) Successful treatment of phantosmia with preservation of olfaction. Arch Otolaryngol Head Neck Surg 117: 1402-1406

222. Leopold DA, Loehrl TA, Schwob JE (2002) Long-term follow-up of surgically treated phantosmia. Arch Otolaryngol Head Neck Surg 128: 642-647

223. Markert JM, Hartshorn DO, Farhat SM (1993) Paroxysmal bilateral dysos-mia treated by resection of the olfactory bulbs. Surg Neurol 40: 160-163

224. Bonfils P et al (2004) Traitement chirurgical d'une parosmie post-rhinitique. Ann Otolaryngol Chir Cervicofac 121: 47-50

225. Fong KJ et al (1999) Olfactory secretion and sodium, potassium-adenosine triphosphatase: regulation by corticosteroids. Laryngoscope 109: 383-388

226. Golding-Wood DG et al (1996) The treatment of hyposmia with intranasal steroids. J Laryngol Otol 110: 132-135

227. Tos M et al (1998) Efficacy of an aqueous and a powder formulation of nasal budesonide compared in patients with nasal polyps. Am J Rhinol 12: 183189

228. Mott AE et al (1997) Topical corticosteroid treatment of anosmia associated with nasal and sinus disease. Arch Otolaryngol Head Neck Surg 123: 367372

229. Stevens MH (2001) Steroid-dependent anosmia. Laryngoscope 111: 200-203

230. Mott AE, Leopold DA (1991) Disorders in taste and smell. Med Clin North Am 75: 1321-1353

231. Klimek L, Eggers G (1997) Olfactory dysfunction in allergic rhinitis is related to nasal eosinophilc inflammation. J Allergy Clin Immunol 100: 159164

232. Jafek BW et al (1987) Steroid-dependent anosmia. Arch Otolaryngol Head Neck Surg 113: 547-549

233. Heilmann S, Hüttenbrink KB, Hummel T (2004) Local and systemic administration of corticosteroids in the treatment of olfactory loss. Am J Rhinol 18: 29-33

234. Ikeda K et al (1995) Efficacy of systemic corticosteroid treatment for anosmia with nasal and paranasal sinus disease. Rhinology 33: 162-165

235. Meltzer EO et al (1998) Subjecive and objective assessments in patients with seasonal allergic rhinitis: effects of therapy with mometasone furoate nasal spray. J Allergy Clin Immunol 102: 39-49

236. El Naggar M et al (1995) Effect of Beconase nasal spray on olfactory function in post-nasal polypectomy patients: a prospective controlled trial. J Otolaryngol 109: 941-944

237. Blomqvist EH et al (2003) Placebo-controlled, randomized, double-blind study evaluating the efficacy of fluticasone propionate nasal spray for the treatment of patients with hyposmia/anosmia. Acta Otolaryngol 123: 862868

238. Heilmann S et al (2004) Untersuchung der Wirksamkeit von systemischen bzw. topischen Corticoiden und Vitamin B bei Riechstörungen. Laryngo-Rhino-Otol 86: 1-6

239. Benninger MS et al (2004) Techniques of intranasal steroid use. Otolaryngol Head Neck Surg 130: 5-24

240. Hardy JG, Lee SW, Wilson CG (1985) Intranasal drug delivery by spray and drops. J Pharmacy Pharmacol 37: 294-297

Newman SP, Moren F, Clarke SW (1987) Deposition pattern from a nasal pump spray. Rhinology 25: 77-82

McGarry GW, Swan IR (1992) Endoscopic photographic comparison of drug delivery by ear-drops and by aerosol spray. Clinical Otolaryngology 17: 359-360

Parnes SM, Chuma AV (2000) Acute effects of antileukotrienes on sinonasal polyposis and sinusitis. Ear Nose Throat J 79: 18-20, 24-25 Bachmann G, Hommel G, Michel O (2000) Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. Eur Arch Otorhinolaryngol 257: 537-541

Rundles W (1946) Prognosis in the neurologic manifestations of pernicious anemia. Blood 1: 209-219

Tanaka O, Mukaino Y (1999) The effect of auricular acupuncture on olfactory acuity. Am J Chin Med 27: 19-24

Stevenson DD et al (1996) Aspirin desensitization treatment of aspirinsensitive patients with rhinosinusitis-asthma: long-term outcomes. J Allergy Clin Immunol 98: 751-758

Moran DT et al (1992) Ultrastructural histopathology of human olfactory dysfunction. Microsc Res Tech 23: 103-110

Yamagishi M, Fujiwara M, Nakamura H (1994) Olfactory mucosal findings and clinical course in patients with olfactory disorders following upper respiratory viral infection. Rhinology 32: 113-118

Henkin RI et al (1976) A double-blind study of the effects of zinc sulfate on taste and smell dysfunction. Am J Med Sci 272: 285-299 Yee KK, Rawson NE (2000) Retinoic acid enhances the rate of olfactory recovery after olfactory nerve transection. Brain Res Dev Brain Res 124: 129132

Hendriks APJ (1988) Olfactory dysfunction. Rhinology 26: 229-251 Nordin S et al (1996) Prevalence and assessment of qualitative olfactory dysfunction in different age groups. Laryngoscope 106: 739-744 Leopold D (1995) Distorted olfactory perception. Handbook of olfaction and gustation. In: Doty RL (ed) Marcel Dekker Inc. New York, p 441-454 Jafek BW, Murrow B, Linschoten M (2000) Evaluation and treatment of anosmia. Curr Opin Otol Head Neck Surg 8: 63-67

Reljanovic M et al (1999) Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy. Free Radic Res 31: 171-179 Packer L, Kraemer K, Rimbach G (2001) Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition 17: 888-895 Hounsom L et al (1998) A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. Diabe-tologia 41: 839-843

Hounsom L et al (2001) Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy. Diabetologia 44: 424-428

260. Garrett NE et al (1997) alpha-Lipoic acid corrects neuropeptide deficits in diabetic rats via induction of trophic support. Neurosci Lett 222: 191-194

261. Coppey LJ et al (2001) Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve. Diabetes 50: 1927-1937

262. van Dam PS et al (2001) Glutathione and alpha-lipoate in diabetic rats: nerve function, blood flow and oxidative state. Eur J Clin Invest 31: 417-424

263. Lynch MA (2001) Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue. Nutr Neurosci 4: 419-438

264. Seiden AM (1997) The intial assessment of patients with taste and smell disorders. Taste and smell disorders. In: Seiden AM (ed) Thieme, New York, p 4-19

265. Garrett-Laster M, Russell RM, Jacques PF (1984) Impairment of taste and olfaction in patients with cirrhosis: the role of vitamin A. Hum Nutr Clin Nutr 38: 203-214

266. Henkin RI (1994) Drug-induced taste and smell disorders. Incidence, mechanisms and management related primarily to treatment of sensory receptor dysfunction. Drug Saf 11: 318-377

267. Ackerman BH, Kasbekar N (1997) Disturbances of taste and smell induced by drugs. Pharmacotherapy 17: 482-496

268. Hudry J, Perrin F, Ryvlin P, Mauguiere F, Royet J-P (2003) Olfactory short-term memory and related amygdala recordings in patients with temporal lobe epilepsy. Brain 126: 1851-1863

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