Kill Your Stutter Program
However, intermittent difficulty with speech was recognized as a rare manifestation of MS 40 years ago (paroxysmal dysarthria). This difficulty with articulation is often associated with difficulty in finding the right word. It is rarely recognized as a manifestation of MS, and many doctors incorrectly regard it as an emotional problem. Misdiagnosis is unfortunate because this disorder is amenable to treatment. There are a number of other brief (typically seconds to minutes) recurrent stereotyped paroxysmal (short duration) manifestations that rarely accompany MS. Sometimes they are mistaken as seizures but respond to anticonvulsant (antiseizure) treatment as if they were seizures. However, they do not require life-long drug therapy but rather long-term (3 to 6 months) treatment. These manifestations of MS usually respond to lower doses of drugs, doses that
Stutter peaks During the amplification of an STR allele it is normal to generate a stutter peak, that is one repeat unit smaller or larger that the true allele smaller alleles are formed in the majority of cases 1 . Stutter peaks are formed by strand slippage during the extension of the nascent DNA strand during PCR amplification (Figure 7.1) 2, 3 . Even in good quality profiles there will be some stutter peaks these are recognizable and do not interfere with the interpretation of the profile. Threshold limits are normally used to aid in the identification and interpretation of stutter peaks, so, for example, while the degree of stutter varies between loci, they are typically less than 15 of the main peak 4,5 - understanding stutter peaks is especially important when interpreting mixtures. Different STR loci have varying tendencies to stutter. This is dependent on the structure of the core repeats shorter di- and trinucleotide repeats are more prone to stutter than are tetra- and...
Imagine a man in his late teens who usually travels to work on the same bus at the same time each day. Quite often on the bus there is also a young woman whom he admires. He glances at her from time to time over the top of his book and thinks that she is lovely. One day she happens to be sitting next to him, looks over and says, 'What are you reading That looks interesting.' He blushes to the roots of his hair and can barely stammer a reply.
Kluin et al. (35) also found a high frequency of dysarthria in PSP, consisting of prominent hypokinetic and spastic components with less prominent ataxic components. In the 14 patients studied, all had hypokinetic and spastic components of dysarthria. Nine patients had ataxic components. When compared with neuropathological findings, the severity of hypokinetic features correlated significantly with the degree of neuronal loss and gliosis in the substantia nigra pars compacta and pars reticulata, but not in the subthalamic nucleus, striatum, or globus pallidus. The severity of spastic and ataxic components did not correlate significantly with neuropathological changes in the frontal cortex or cerebellum. In an earlier study of 44 patients with PSP (36), all were found to have dysarthria with variable degrees of spasticity, hypokinesia, and ataxia. Twenty-eight patients had all three components, and 16 patients had only two components. Twenty-two patients (50 ) had predominantly...
It seems clear that global development has come at a terrible cost. Yet this is not even a good Faustian bargain, for the 'magic' of development has not worked for the vast majority of the world's citizens. There have never been more people living in absolute poverty and the United Nations Development Programme Human Development Report charts the failure of the stuttering engine of the global economy to extend its reach to the global poor.11 Life expectancy at birth in 2001 was 77 years in OECD countries, but only 64 years in sub-Saharan Africa, 44 in Tanzania and 39 in Malawi Gross Domestic Product per capita was over US 23,000 in OECD countries, 1800 in Sub-Saharan Africa, and only 520 in Tanzania.
Stammering Its Cause and Its Cure
This book discusses the futility of curing stammering by common means. It traces various attempts at curing stammering in the past and how wasteful these attempt were, until he discovered a simple program to cure it. The book presents the life of Benjamin Nathaniel Bogue and his struggles with the handicap. Bogue devotes a great deal of text to explain the handicap of stammering, its effects on the body and psychology of the sufferer, and its cure.