Abnormalities of Cranial Development and Ossification

Variability is the outstanding characteristic of the pediatric skull from infancy throughout childhood and adolescence. Variations may affect skull size and shape, degree of mineral content, depth of vascular grooves, appearance of the diploic structure and con-volutional markings, pattern of sutural ossification and their width, etc. These variations can be so conspicuous as to become indistinguishable from true pathologic changes unless other manifestations of the disease are taken into consideration.

In this section, some of these developmental variants are discussed together with a number of frankly pathologic situations; we also discuss how they relate to the complex phenotypes of several inherited disorders.

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