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Anabolic Running Review

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Anabolic Running Review Summary


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Juicing for Your Manhood Summary

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An under-appreciated cause ofosteoporosis in patients with GI or liver disease is hypogonadism. Patients treated with glucocorticoids for any reason suppress gonadal and adrenal sex hormone production via suppression of the hypothalamic-pituitary axis. Women with CD, celiac disease or severe weight loss from any cause often do not menstruate and must be treated as if postmenopausal (Sher et al, 1994). Women that are postmenopausal and have coexistent GI diseases such as CD or celiac disease are at very high risk for osteoporosis and fractures (Clements et al, 1993). Similarly women with primary biliary cirrhosis (PBC) who are postmenopausal are at significantly higher risk than younger women for osteoporosis and fractures (Solerio et al, 2003). Estrogen replacement, especially in younger women who are not postmenopausal, should be considered. Estrogen replacement therapy has been shown to be safe and effective in patients with PBC (Monegal et al, 1997). Men with CD, celiac disease,...

Male Sexual Function

There are few data on male sexual function. It would seem that no unit has been able to follow up its own patients into mature adult life. It is recorded that no adult patients have normal faecal continence, which is certainly a bad start for any individual wishing to share his life and bed with another 34 . Nonetheless, in this study there was no difference in arrangements for family life between patients and the normal population in The Netherlands, and the same proportions were cohabiting. There was no specific reference to sexual function, but it was striking that 24 of patients never had a lasting relationship 34 .

Hormonal Abnormalities

As would be expected, stallions with low circulating testosterone levels have depressed DSO as well as decreasing libido. As mentioned previously, testosterone, hCG and GnRH therapy have been used with mixed success to address this problem. The lack of success may well be due to the fact that depressed pituitary function is the cause of infertility in only 1 of cases (Boyle et al., 1991 Roger and Hughes, 1991). Abnormal hormone levels may be associated with hypothyroidism, resulting in delayed puberty, smaller testes, decreased spermatozoan production and decreased libido. Feminization of the genitalia may also be observed. It has been postulated that changes in thyroid function may be the cause of stallion summer infertility associated with elevated environmental temperatures (Brachen and Wagner, 1983).

Effect of Hyperinsulinemia on Hyperandrogenism in PCOS

In vivo data also suggest that hyperinsulinemia is associated with an increased level of circulating testosterone in PCOS. When pancreatic insulin secretion was suppressed in women with PCOS by diazoxide, both serum total and free testosterone levels decreased (8). However, diazoxide's suppression of insulin release in healthy normal women did not result in changes in serum testosterone levels (9). Hence, hyperinsulinemia seems to play a role in hyperandrogenemia in PCOS, and women with PCOS may be more susceptible than normal women to stimulation of ovarian androgen production by insulin.

Regulation of Prostatic Function and Growth

Although androgens play a key role in the regulation of prostatic growth, function, and disease, it is now clear that they act in concert with, or as a backdrop for, a host of other regulatory pathways. Prostatic growth and the development of differentiated function take place under the influence of increased expression of testosterone during puberty,1,2 although castration prior to puberty does not entirely prevent subsequent prostatic growth.155,156 Once its mature size is reached, however, the prostate and other accessory sex glands cease growing, even though testosterone levels remain elevated. Supraphysiologic doses of exogenous testosterone do not From an evolutionary standpoint, the majority of mammals are seasonal breeders and show drastic decreases in testosterone levels during the nonbreeding season. Thus, there must be a mechanism to either maintain prostatic function during the nonbreeding season or reinitiate it during sexual recrudescence.36,37 It is not unreasonable to...

Molecular Epidemiology

Prostate cell division is controlled by testosterone after intracellular conversion to its reduced form, dihy-drotestosterone, by 5 alpha-reductase. Ross and others have found evidence suggesting that racial or ethnic variations in prostate cancer are due in part to underlying differences in androgen secretion and metabolism. Young adult African American men have at least 10 higher circulating testosterone levels than do young adult Caucasian men. This difference, if sustained over an extended period, is probably sufficient to explain the 60 to 70 higher prostate cancer rates in older adult African Americans compared to Caucasians.49 The authors further report that African American women have much higher first-trimester testosterone levels than do Caucasian women.50 They speculate that these high testosterone levels contribute to high rates of prostate cancer in male offspring, possibly by their impact on the hypothalamic-pituitary-testicular feedback system, the gonadostat, causing...

Regulation of stem cell renewal and differentiation

In several renewing tissues, stem cells were found to occupy specific areas. For example, in the intestine, stem cells reside near the bottom of the crypts (42), and stem cells in the bone marrow are supposed to occupy specific niches (43). Until very recently, in the seminiferous epithelium no such niches were found for spermatogonial stem cells. Now, it has become clear that most spermatogonial stem cells are present in those areas of seminiferous tubules that border interstitial tissue (10) (Fig. 4). Apparently, the interstitial tissue affects stem cell behavior. One could speculate that this is caused by the high testosterone levels present in these areas. In this respect, it is interesting that high testosterone levels have been found to prevent the differenti-ation of Aal spermatogonia into A1 spermatogonia (44-46). Possibly, testosterone also has a role in regulating stem cell behavior. However, it has to be kept in mind that germ cells do not possess androgen receptors, so...

Anemia due to CKD in the Elderly

CKD has been reported to be the principal cause of anemia in more than 8 of older subjects, and a contributing cause in others (27). The pathophysiologic basis for anemia related to CKD in older individuals is likely similar to that of younger subjects, complicated perhaps by a greater impact of underlying inflammatory processes, and in men, an age-related decline in testosterone levels (28). Although information is conflicting, data from the Baltimore Longitudinal Study on Aging revealed a rise in serum erythropoietin level over time in that sample of older adults, regardless of the presence or absence of anemia (29, 30). The increase in erythropoietin levels was less marked in subjects with hypertension or diabetes mellitus, perhaps reflecting some underlying CKD, either age-related or due to these other conditions. While some studies suggest that the erythropoietin production in response to anemia and erythropoietin responsiveness is blunted in healthy elderly subjects, others have...

Gonadotropin Ovulation Induction

In general, ovulation induction with gonadotropins in clomiphene-resistant PCOS patients is less successful than in patients with hypogonadotrophic hypogonadism (103). However, women with PCOS are more sensitive to gonadotropin stimulation compared with spontaneously cycling women. This increased sensitivity appears to result from a larger pool of small antral follicles available for recruitment, rather than on differences in the FSH threshold level (104). Women with PCOS receiving gonadotropins for ovulation induction are particularly prone to a higher risk of overstimulation, multiple pregnancy, and OHSS rates (105).

Options for Hormonal Therapy

Oral contraceptives contain two agents, an estrogen (generally ethinyl estradiol) and a progestin. In their early formulations, oral contraceptives had high concentrations of over 100 g of estrogen. In doses higher than 100 g, estrogens can suppress sebum production. Estrogens also act hepatically to increase the synthesis of sex-hormone-binding globulin. Circulating testosterone levels are reduced by the increased sex-hormone-binding globulin production, leading to a decrease in sebum production. Oral contraceptives inhibit the ovarian production of androgens by suppressing ovulation. This, in turn, decreases serum androgen levels and reduces sebum production.

Hormonal regulation and control of spermatogenesis

The functions of the hypothalamus and the pituitary are also affected by testicular hormones. Testosterone has a negative feedback effect on both, reducing the concentration of GnRH released and the sensitivity of the anterior pituitary to GnRH stimulation (Thompson et al., 1979b Irvine et al., 1986). In response to this long negative feedback loop, the pituitary produces less LH. This negative feedback may also be attributed to the effect of dihydrotestosterone and possibly oestrogens and maybe progesterone (Amann, 1993b). As a result of this decline in LH levels, the stimulation of the Leidig cells is depressed, so reducing the production of testosterone. The decline in circulating testosterone levels reduces the negative feedback loop and allows activation of the hypothalamic-pituitary axis and further pulsatile release of LH and a corresponding increase in testosterone. Testosterone also exerts its effect on spermatogenesis, allowing completion of the process and spermatozoan...

Endocrine Control of Puberty

Endocrine Control Male Reproduction

The testes secrete substantial amounts of testosterone in the first trimester (3 months) of fetal development. Even in the first few months of infancy, testosterone levels are about as high as they are in midpuberty, but then the testes become dormant for the rest of infancy and childhood. From puberty through adulthood, reproductive function is regulated by hormonal links between the hypothalamus, pituitary, and gonads the brain-testicular axis (fig. 27.13). LH stimulates the interstitial cells of the testis to secrete androgens, mainly testosterone. In the male, LH is sometimes called interstitial cell-stimulating hormone (ICSH). FSH stimulates the sustentacular cells to secrete androgen-binding protein (ABP). ABP is thought to raise testosterone levels in the seminiferous tubules and epi-didymis, but this remains unproven. Without FSH, however, testosterone has no effect on the testis. Germ cells have no androgen receptors and do not respond to it. Nevertheless, testosterone...

Causes and Symptoms of Smell Disorders

Currently we distinguish between congenital anosmia occurring as an isolated defect or occurring within the context of a syndrome 191 . Isolated congenital anosmia seems to occur more often than previously believed. Apart from the typical patient history of no odor memories, only MR imaging leads to a more definitive diagnosis 192, 193 . In the frontal imaging planes just tangential to the eye bulbs, hypoplastic or aplastic olfactory bulbs can be visualized. This plane also allows an evaluation of the olfactory sulcus which is flattened if the olfactory bulb is absent or aplastic. This is a useful indicator of congenital anosmia, especially since the bulb is not always easy to identify. Among cases of congenital anosmia as part of a syndrome, the Kallmann-Syndrom 194 is the disorder in which it is most frequently encountered. This is an anosmia associated with hypogonado-tropic hypogonadism clinically characterized by infertility and anosmia, where infertility can be reversed by...

Screening for an Endocrine Disorder

A medical history and physical examination directed towards eliciting any symptoms or signs of hyperan-drogenism should be performed. Screening tests for hyperandrogenism include serum DHEAS, total testosterone, free testosterone, and luteinizing hormone follicle-stimulating hormone (LH FSH) ratio. In some cases additional information can be gained from a serum level of 17-hydroxypregnenolone. These tests should be obtained in the luteal phase of the menstrual cycle (within 2 weeks prior to the onset of menses). If a patient is taking oral contraceptives, any underlying hyperandrogenism would be masked. Therefore, it is required that the patients dis If the ovary is the source of androgens, this is most commonly indicated by an elevation in testosterone. Serum total testosterone in the range of 150-200 ng dl or an increased LH FSH ratio (greater than 2-3) can be found in cases of polycystic ovary disease which can be characterized by irregular menstrual periods, reduced fertility,...

Commencement of reproductive activity

Puberty heralds the start of reproductive activity in the stallion. The exact timing of puberty is unclear but has been defined as the time at which a stallion can produce 50 X 106 spermatozoa per ejaculate with greater than 10 progressive motility. Using these parameters, puberty is seen to commence at 21 months (Clay and Clay, 1992). The exact timing of puberty is known to be affected by several factors, including breed, management and the rate of stallion growth and development. Classically puberty is considered to commence between 17 and 22 months of age (Nishikawa, 1959b). Histological examination of testicular tissue indicates that spermatogenesis commences in utero with the migration of primordial cells into the fetal gonads (Everett, 1945). These primordial cells undergo division to produce gonocytes, which are found between the Sertoli cells. Puberty then heralds the further division of these to produce spermatogonia. Histological work on the changes within the testes,...

Metformin Weight Loss and PCOS

It is likely that weight reduction plays the most significant role in restoration of ovulation in obese women with PCOS and that this may be the primary mechanism for the effects noted with metformin, independent of its insulin-sensitizing effects (14). More recently, drugs that target weight loss have been compared with metformin therapy in women with PCOS. Treatment with orlistat for 3 months led to a 4.7 reduction in body weight, a more significant loss than was observed in metformin-treated women (1.0 ). Serum testosterone levels declined significantly in both groups with no change in levels of SHBG. This agent has potential as an adjunct to the treatment of PCOS (15). The effects of metformin (1700 mg day) vs acarbose (300 mg day) on insulin resistance, hormone profiles, and ovulation rates in patients with clomiphene citrate-resistant PCOS have recently been assessed (16). The ratio of LH to follicle-stimulating hormone (FSH) and total testosterone concentrations decreased and...

Background On Polycystic Ovarian Syndrome Among Adolacents

The adrenals and ovaries contribute variably to the circulating levels of androgens in adult women (15). Generally, it is thought that A4 is derived in roughly equal amounts from the ovary and the adrenal, while testosterone is derived approximately 25 from the adrenal, 25 from the ovary, and 50 from the peripheral conversion of A4. DHT is produced in peripheral tissues from testosterone and circulates at levels about one-third to one-half that of testosterone. DHEA and DHEAS are almost exclusively of adrenal origin. DHEA is secreted in a pulsatile manner and demonstrates a diurnal rhythm similar to that of cortisol in young women (16). Because of the low metabolic clearance rate (MCR) of DHEAS, however, there are only minor changes in its concentration throughout the day. Androstenedione and testosterone levels also exhibit a diurnal rhythm (15), although less variable than that of DHEA and cortisol. Ovarian suppression in adult women because of the ingestion of oral contraceptive...

Fetal Nutrition and Timing of Puberty

These findings suggest that postnatal undernutrition has a transient influence on follicle growth and development. In male rats, both models showed delayed onset of puberty and impaired testicular function, as shown by decreased testosterone levels. These data indicate that early malnutrition during different critical developmental time windows may result in different long-lasting effects on pubertal development in both humans and rats.

Treatment of Hemochromatosis

Therapy for HH is relatively simple and quite effective. Phlebotomy has been shown to effectively remove excess iron stores without significant side effects. If therapeutic phlebotomy is started before the development of cirrhosis, morbidity and mortality are significantly reduced. Some clinical features of iron overload respond better to phlebotomy than others. Malaise, fatigue, abdominal pain, skin pigmentation, and insulin requirements in diabetic patients tend to improve, whereas arthropathy and hypogonadism are less responsive. Given these findings, early identification and initiation of therapeutic phlebotomy should be the goal.


The sex of the fish had a sigificant influence on the abundance of the parasites in total and also on particular species with the bias in all cases being in favour of the female fish. This review shows that sex bias in parasitism is generally not strong and that male bias in parasitism is not a general rule. Taken as a whole, the results fail to support most of the predictions based on the Hamilton-Zuk and the immunocompetence hypotheses. Possible hypotheses to explain why parasitism tends to be higher in female than in male trout include testosterone immunosuppression, corticosteroid-based immune suppression and differences between the size and behaviour of the sexes. However, the latter two hypotheses have more credence, although testosterone levels are higher in female than male trout.

Perimenopausal Stage

Burger and associates (35) also conducted longitudinal studies of women through the menopausal transition. As found by others, they noted little, if any, change in total testosterone levels leading up to, during, and for several years after menopause. However, reductions in SHBG levels were observed in concert with the reduction in estradiol observed leading up to the menopause and thereafter. The net effect of declining SHBG levels in the face of unwavering levels of testosterone is to increase the free testosterone fraction by 80 over the interval beginning 4 years prior to menopause and ending 2 years after the menopause. If free testosterone levels are actually increased during the perimenopausal period, this could have physiological impacts on androgen-dependent systems, such as libido, in these women. Although the utilization of hormone replacement therapy (estrogen with or without a progestin) in postmenopausal women is in a period of flux because of concerns relating to...

Hormone Levels

The androgen sensitivity of prostate cancer has been well described over the past five decades. Androgen withdrawal is clearly recognized as one of the cornerstones of management in patients with advanced prostate cancer disease. In addition, androgens are necessary for normal prostatic growth and development during puberty. Interestingly, however, data suggesting that variations in serum testosterone or DHT are a risk factor for prostate cancer in normal men are minimal or contradictory. A variety of studies measuring these potent androgens in both typical case-control and prospective studies indicate no significant elevation in risk associated with alterations in circulating testosterone levels.18-21 Low DHT levels have been associated with elevations in prostate cancer risk in some19 but not all20,21 studies. Low DHT testos-terone ratios have also been implicated as a prostate cancer risk factor in some18 but not all studies. Taken together, studies of hormones and prostate cancer...

Human Pheromones

There is an abundance of anecdote, but no clear experimental evidence, that human body odors affect sexual behavior. There is more adequate evidence, however, that a person's sweat and vaginal secretions affect other people's sexual physiology, even when the odors cannot be consciously smelled. Experimental evidence shows that a woman's apocrine sweat can influence the timing of other women's menstrual cycles. This can produce a so-called dormitory effect in which women who live together tend to have synchronous menstrual cycles. The presence of women stimulates men's beards to grow faster, and the presence of men seems to influence female ovulation. When a woman is ovulating or close to that time, and therefore fertile, her vaginal secretions contain pheromones called copulines. These have been shown to raise men's testosterone levels.


Men with Klinefelter's syndrome (obesity, hypogonadism, aspermatogenesis, increased urinary gonadotropins, and gynecomastia), identified by an XXY karyotype are estimated to have a 20- to 50-fold increase in risk for breast cancer and a 3 percent lifetime risk.26-29 Nevertheless, cases of Klinefelter's syndrome are not regularly found in reported series of males with breast cancer the frequency varies widely, from 0 to 7.5 percent.

The accessory glands

Ultrasound Bulbourethral Glands

The vesicular glands, or seminal vesicles, are paired, multi-lobed glands lying either side of the bladder and exiting again near the exit of the bulbourethral glands. They are, on average, 160-200 mm in length, 25 mm in width and 13 mm in height, and weigh 25-30 g (Gebauer et al., 1974b Little and Woods, 1987). The main function of these glands seems not to be (as first suggested) spermatozoan storage, but rather the production of the gel-like last fraction of semen ejaculated. Work by Weber et al. (1990) indicated that the decrease in size of the vesicular glands post ejaculation is positively correlated with the volume of gel evident in that ejaculate. The vesicular glands' function, however, is apparently not exclusively gel production. Weber and Woods (1993) demonstrated that there was fluid in the vesicular gland's excurrent ducts in only six out of 17 ejaculates that resulted in gel. It is likely that the vesicular glands are also responsible for secretions within the main...


Hormonal therapy is an option for treatment when acne is not responding to conventional therapy. If there are signs of hyperandrogenism, an endocrine evaluation is indicated, consisting of an assessment of DHEAS, total and free-testosterone levels and an LH FSH ratio. Although an indication for hormonal therapy is hyperandro-genism, women with normal serum androgen levels also respond well to treatment. Hormonal therapy choices consist of androgen-receptor blockers, androgen-produc-tion blockers, and, potentially in the future, androgen-metabolizing enzyme inhibitors. The mainstays of hormonal therapy include oral contraceptives and spirono-lactone. Other agents to choose from are cyproterone, flu-tamide, and glucocorticoids.

Triangular Facies

Russell Silver Syndrome Pictures

In the same infant note the cryptorchidism. Genital hypoplasia and hypogonadism are commonly present in Russell-Silver syndrome. Figure 3.179. In the same infant note the cryptorchidism. Genital hypoplasia and hypogonadism are commonly present in Russell-Silver syndrome.

Testicular hormones

Testosterone Stallions

Concentrations were significantly higher at 6.00 hours and 18.00 hours, the average increase being 100 (Pickett et al., 1989). Sexual activity shows a similar diurnal variation and it may be postulated that, in the wild, mating activity is increased at dusk and dawn, as at these times the horse is at least risk from predators. Testosterone levels are also reported to vary with testis size and to increase with age. It has been postulated that this may account for the variation in spermatozoan production evident between stallions within a single breeding season (Berndtson and Jones, 1989).

Prepubertal Acne

Lucky et al. 27 in a 5-year longitudinal cohort study of 871 girls stated clearly the predictor factors of an acne vulgaris study. They evaluated acne versus hormone levels at various ages before and after menarche. They were able to conclude that there were no ethnic differences in acne or hormone levels in the groups studied that included black and white girls. A progressive increase in number of acne lesions with age and maturation was found. The most common acne was comedonal girls with severe acne at the end of the study had more comedones and inflammatory lesions by the age of 10 years and 2.5 years before menarche. The onset of menarche was also earlier in cases with severe acne and associated to higher levels of serum DHEAS and total and free testosterone compared to girls with mild-to-moderate disease. Early development of comedonal acne, DHEAS, free and total testosterone were good predictors for severe comedonal acne or a long-term disease 27 .


Sex hormone levels are also influenced by the degree of overweight. women with PCOS have lower sex hormone-binding globulin (SHBG) levels, with more pronounced SHBG reduction in obese women with PCOS, especially if they present with abdominal obesity (6). Lower SHBG levels increase the bioavailability of sex hormones, and therefore increase hyperandrogenemia in obese PCOS women. Both total and free testosterone levels are increased in obese PCOS compared to normal-weight women with PCOS because of the combination of increased androgen production and lower SHBG (6).


Gel Free Volume Sperm

In addition to the above effects, breeding outside the natural season is reported to increase the percentage of spermatozoa with morphological abnormalities (Van der Holst, 1975). The reduction in a stallion's libido during the non-breeding season may be accounted for by a decrease in the number of Leidig cells and so by implication a reduction in circulating testosterone levels (Johnson and Tatum, 1989).

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