The usual PTC demonstrates an ill-defined margin indicating an invasive neoplasm. The cut surface is granular and may show cystic change. The tumor is firm to palpation and varies from white to tan. The microscopic defining features of this neoplasm are papillary formations and nuclear changes. Papillae are formed by a central fibrovascular stalk covered by neoplastic epithelium (Figure 2-8). The cytoplasm of the tumor cells is denser in quality than the cytoplasm of follicular lesions. The characteristic
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