Germline mutations in the RET proto-oncogene are responsible for hereditary MTC, and somatic point RET mutations have also been identified in some sporadic MTC (in about 25%).3 The RET gene, located on chromosome 10q11.2, encodes a transmembrane receptor protein. The RET receptor belongs to the family of receptor tyrosine kinase proteins such as met, neu, and trk.3 The RET receptor
Cadherin-like region Cysteine-rich region
Tyrosine kinase region 1 Tyrosine kinase region 2
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