Molecular Biology Of

Germline mutations in the RET proto-oncogene are responsible for hereditary MTC, and somatic point RET mutations have also been identified in some sporadic MTC (in about 25%).3 The RET gene, located on chromosome 10q11.2, encodes a transmembrane receptor protein. The RET receptor belongs to the family of receptor tyrosine kinase proteins such as met, neu, and trk.3 The RET receptor

staining. Note the interspersed spindle and polyglonal cells sepa- Figure 3-5. Calcitonin immunohistochemistry of medullary thyroid rated by fibrinous septae (x10 original magnification). cancer with adjacent normal thyroid tissue.

Cadherin-like region Cysteine-rich region

Tyrosine kinase region 1 Tyrosine kinase region 2

Exon

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