Treatment

Thyroid Factor

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The guiding principle in managing patients with DTC is to avoid either overaggressive treatment in a patient with an excellent prognosis or inadequate therapy for the unusual patient with a high risk of tumor recurrence and possible death from thyroid cancer. However, what constitutes the appropriate therapy in patients with DTC is still a subject of intense debate because no prospective randomized clinical trials exist and none are likely to be done. Given the slow progression and good prognosis of the disease, it is difficult to demonstrate a beneficial

Years followed

Figure 2-10. Disease-free survival curves for patients with differentiated thyroid carcinoma by pTNM staging (p < .0001 among all stages). Reproduced with permission from Loh KC et al.15

Years followed

Figure 2-10. Disease-free survival curves for patients with differentiated thyroid carcinoma by pTNM staging (p < .0001 among all stages). Reproduced with permission from Loh KC et al.15

effect of therapy unless very large cohorts are studied over several decades.

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