Adrenal Disorders

Cushing26 syndrome is excess cortisol secretion owing to any of several causes: ACTH hypersecretion by the pituitary, ACTH-secreting tumors, or hyperactivity of the adrenal cortex independently of ACTH. Cushing syndrome disrupts carbohydrate and protein metabolism, leading to hyperglycemia, hypertension, muscular weakness, and edema. Muscle and bone mass are lost rapidly as protein is catabolized. Some patients exhibit abnormal fat deposition between the shoulders ("buffalo hump") or in the face ("moon face") (fig. 17.26). Long-term hydrocortisone therapy can have similar effects.

Adrenogenital syndrome (AGS), a state of adrenal androgen hypersecretion, commonly accompanies Cush-ing syndrome. In children, AGS often causes enlargement of the penis or clitoris and the premature onset of puberty. Prenatal AGS can result in newborn girls exhibiting masculinized genitalia and being misidenti-fied as boys (fig. 17.27). In women, AGS produces such masculinizing effects as increased body hair, deepening of the voice, and beard growth.

Was this article helpful?

0 0
Reducing Blood Pressure Naturally

Reducing Blood Pressure Naturally

Do You Suffer From High Blood Pressure? Do You Feel Like This Silent Killer Might Be Stalking You? Have you been diagnosed or pre-hypertension and hypertension? Then JOIN THE CROWD Nearly 1 in 3 adults in the United States suffer from High Blood Pressure and only 1 in 3 adults are actually aware that they have it.

Get My Free Ebook

Post a comment