It is common knowledge that a diet high in sugars causes us to put on fat and gain weight. Lipogenesis employs compounds such as sugars and amino acids to synthesize the triglyceride precursors, glycerol and fatty acids. PGAL, one of the intermediates of glucose oxidation, can be converted to glycerol. As glucose and amino acids enter the citric acid cycle by way of acetyl-CoA, the acetyl-CoA can

Saladin: Anatomy & I 26. Nutrition and I Text I © The McGraw-Hill

Physiology: The Unity of Metabolism Companies, 2003 Form and Function, Third Edition



Lipolysis Cycle
Figure 26.9 Pathways of Lipolysis and Lipogenesis in Relation to Glycolysis and the Citric Acid Cycle. Name the acid-base imbalance that results from the accumulation of the ketone bodies shown here.

also be diverted to make fatty acids. The glycerol and fatty acids can then be condensed to form a triglyceride, which can be stored in the adipose tissue or converted to other lipids. These pathways are summarized in figure 26.9.

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