Although changes in RV structure and function over time would be expected to be seen in affected ARVC/D probands, there are no published data reporting on serial changes. Prior echocardiographic studies have included individuals at varying time points in the disease process, and it is unclear what happens to RV structure and function in an affected individual over years. Nava et al. reported on mild, moderate and severe forms of the disease in families with ARVC/D  and observed that a subset of patients that were unaffected at initial screening later developed structural changes. The rate of such progression remains unknown, as well as whether those with mild forms progress to have more severe forms of the disease over time.
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