Human Studies

Two important morphological features characterize ARVC/D: (a) progressive loss of myocardium, mainly in the right ventricle (RV), with fibrofatty replacement and (b) presence of patchy inflammatory infiltrates [15].

1. Fibrofatty replacement of myocardium. Morphologic alterations in patients with ARVC/D usually begin in the subepicardium or mediomural layers of the RV and progress to af

Table 9.1 • Inflammatory infiltrate in ARVC/D

Author No of Myocarditis patients %

Fontaine et al.,1990 [14] 27 74

Total 122 69

Fig. 9.1 • Endomyocardial biopsy from a patient with ARVC/D. Inflammatory cell infiltration is mainly represented by activated T-lymphocytes IHC for CD25. Original magnification x50

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